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Ketoconazole is an antifungals

Posted by Ashraf Ali Tuesday, January 25, 2011

Ketoconazole is an antifungals in that it works to stop the growth of fungi. It is helpful to cure fungi infections especially the ones on the epidermis and nails. It is particularly used for people who have a compromised immune mechanism such as HIV sufferers and sufferers going through chemotherapy treatment. The antifungal drug is sold under the brand names such as Nizoral shampoo from Johnson and Johnson, USA and Sebizole from Douglas Pharmaceuticals, Australia. The medication is sold in different forms including tablets, topical cream or anti dandruff shampoo.



History



The drug Ketoconazole was first discovered in the year 1976 by United states laboratory scientists. However, the drug underwent various clinical tests and further laboratory examinations before it got the approval to be used as medication to be sold commercially. It was formally released for use and commercial distribution in 1981 with the approval of FDA and the approval followed that of Griseofulvin as being an oral treatment for infections caused by fungi attacks.



The Drug Workings



Ketoconazole's work is to repress the growth of fungi that aids the fungi cell membrane and fungi enzymes that results in the growing of fungi. Also, it can be utilized in a number of other medication and chemical compounds such as steriods and in precursors of testosterone due to this synthesis suppression.



Treatment Of Hair Loss



A few studies through the years has shown that Nizoral shampoo can remedy hair loss in men. In 1988, research exposed that a 2 per cent addition of Ketoconazole could significantly produce hair for anybody experiencing thinning hair. However, the experiments were not exhaustive and other experiments have been conducted since then, These experiments reveal that the Nizoral shampoo has a hair growth stimulant that can be used to significantly reverse the effects of hair loss.



Germs Resistant To The Antifungal



Never all fungi get suppressed by the Nizoral shampoo or several other types of Ketoconazole medicine. Some varieties of fungi have been noticed to be resistant to this remedy and can thus not cure the diseases brought on by the fungi. Especially in cases of HIV, the drug has been noted as being successfully resisted by various yeast infections such as Candida albicans. This resistance has been explained as being a mutation of the fungi during the synthesis process. Therefore, if the specific fungi infection does not go away with the treatment, you should seek medical advice and have your doctor get you a replacement drug for your infection.



Side effects of the medication



The Nizoral shampoo has mild uncomfortable side effects on a few of the sufferers including dryness of the epidermis and also oiliness or excessive dryness of the hair and the scalp. For the other types of mediation, there are possible itchiness and skin rash especially with the cream and other side effects including excessive irritation or sting like effects which commence with the use of the medication. If you have concerns with the side effects, you should discuss this with your doctor. You should also alert the doctor in case such side effects arise so as to have them recommend a solution for the side effects. However, by and large, these side effects are very rare and occur only to about 1% of the users.

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